Identification of the NF-κB activating protein-like locus as a risk locus for rheumatoid arthritis.

ABSTRACT:

Objective

To fine-map the NF-κB activating protein-like (NKAPL) locus identified in a prior genome-wide study as a possible rheumatoid arthritis (RA) risk locus and thereby delineate additional variants with stronger and/or independent disease association.

Methods

Genotypes for 101 SNPs across the NKAPL locus on chromosome 6p22.1 were obtained on 1368 Canadian RA cases and 1471 controls. Single marker associations were examined using logistic regression and the most strongly associated NKAPL locus SNPs then typed in another Canadian and a US-based RA case/control cohort.

Results

Fine-mapping analyses identified six NKAPL locus variants in a single haplotype block showing association with p≤5.6×10(-8) in the combined Canadian cohort. Among these SNPs, rs35656932 in the

SUBMITTER: Xie G 

PROVIDER: S-EPMC3686260 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature