Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies.

ABSTRACT:

Context

Polymorphisms in the gene encoding the glucocorticoid receptor (GR) regulating co-chaperone FKBP5 have been shown to alter GR sensitivity and are associated with an increased risk to develop posttraumatic stress disorder (PTSD).

Objective

To investigate interactions of the FKBP5 single-nucleotide polymorphism rs9296158 and PTSD symptoms on baseline cortisol level, low-dose dexamethasone suppression, and whole-blood gene expression.

Design

Association of FKBP5 genotypes and PTSD symptoms with endocrine measures and genome-wide expression profiles.

Setting

Waiting rooms of general medical and gynecological clinics of an urban hospital at Emory University.

Participants

The 211 participants were primarily African American (90.05%) and of low socioeco

SUBMITTER: Mehta D 

PROVIDER: S-EPMC3686481 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature