Community Structure Analysis of Gene Interaction Networks in Duchenne Muscular Dystrophy.

ABSTRACT: Duchenne Muscular Dystrophy (DMD) is an important pathology associated with the human skeletal muscle and has been studied extensively. Gene expression measurements on skeletal muscle of patients afflicted with DMD provides the opportunity to understand the underlying mechanisms that lead to the pathology. Community structure analysis is a useful computational technique for understanding and modeling genetic interaction networks. In this paper, we leverage this technique in combination with gene expression measurements from normal and DMD patient skeletal muscle tissue to study the structure of genetic interactions in the context of DMD. We define a novel framework for transforming a raw dataset of gene expression measurements into an interaction network, and subsequently apply algorithms

SUBMITTER: Narayanan T 

PROVIDER: S-EPMC3686745 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature