Questionnaire based assessment of risk factors for primary biliary cirrhosis.

ABSTRACT:

Background

Primary biliary cirrhosis is a cholestatic liver disease characterized by immune-mediated destruction of bile ducts. Its pathogenesis is largely unknown, although complex interactions between environment and genetic predisposition are proposed.

Aims

Identify disease risk factors using a detailed patient questionnaire and compare study findings to 3 published reports.

Methods

Questionnaire data were prospectively collected from 522 cases and 616 controls of the Mayo Clinic Primary Biliary Cirrhosis Genetic Epidemiology Registry. Case and control responses were compared using logistic regression, adjusting for recruitment age, sex, and education level.

Results

Cases reported ever regularly smoking cigarettes more frequently than controls (P < 0.001). H

SUBMITTER: Lammert C 

PROVIDER: S-EPMC3686972 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature