Risk of precancer determined by HPV genotype combinations in women with minor cytologic abnormalities.

ABSTRACT:

Background

Studies suggest that testing for individual human papillomavirus (HPV) genotypes can improve risk stratification in women with minor cytologic abnormalities. We evaluated genotyping for HPV16, HPV16/18, and HPV16/18/45 in carcinogenic HPV-positive women with atypical squamous cells of undetermined significance (ASCUS) and low-grade squamous intraepithelial lesion (LSIL) cytology.

Methods

For women enrolled in the ASCUS-LSIL Triage Study (ALTS), we calculated the age-stratified (<30 and 30+ years) positivity and cumulative risk over two years of cervical intraepithelial neoplasia grade 3 or worse (CIN3+) when testing positive or negative for three genotype combinations: HPV16, HPV16/18, and HPV16/18/45.

Results

Among women with ASCUS cytology, HPV16 positivi

SUBMITTER: Gage JC 

PROVIDER: S-EPMC3687215 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature