MAPs: a database of modular antibody parts for predicting tertiary structures and designing affinity matured antibodies.

ABSTRACT:

Background

The de novo design of a novel protein with a particular function remains a formidable challenge with only isolated and hard-to-repeat successes to date. Due to their many structurally conserved features, antibodies are a family of proteins amenable to predictable rational design. Design algorithms must consider the structural diversity of possible naturally occurring antibodies. The human immune system samples this design space (2 1012) by randomly combining variable, diversity, and joining genes in a process known as V-(D)-J recombination.

Description

By analyzing structural features found in affinity matured antibodies, a database of Modular Antibody Parts (MAPs) analogous to the variable, diversity, and joining genes has been constructed for the prediction of a

SUBMITTER: Pantazes RJ 

PROVIDER: S-EPMC3687570 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature