Ontology highlight
ABSTRACT:
SUBMITTER: Delaney JR
PROVIDER: S-EPMC3687586 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Aging cell 20121225 1
Although environmental stress likely plays a significant role in promoting aging, the relationship remains poorly understood. To characterize this interaction in a more comprehensive manner, we examined the stress response profiles for 46 long-lived yeast mutant strains across four different stress conditions (oxidative, ER, DNA damage, and thermal), grouping genes based on their associated stress response profiles. Unexpectedly, cells lacking the mitochondrial AAA protease gene AFG3 clustered s ...[more]