Ontology highlight
ABSTRACT:
SUBMITTER: Lee MW
PROVIDER: S-EPMC3687591 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
BioMed research international 20130604
A microarray analysis was performed to investigate whether ex vivo culture conditions affect the characteristics of MSCs. Gene expression profiles were mainly influenced by the level of cell confluence rather than initial seeding density. The analysis showed that 276 genes were upregulated and 230 genes downregulated in MSCs harvested at ~90% versus ~50% confluence (P < 0.05, FC > 2). The genes that were highly expressed in MSCs largely corresponded to chemotaxis, inflammation, and immune respon ...[more]