Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome.

ABSTRACT: We have investigated the interrelationship between diet, gut microbial ecology, and energy balance using a mouse model of obesity produced by consumption of a prototypic Western diet. Diet-induced obesity (DIO) produced a bloom in a single uncultured clade within the Mollicutes class of the Firmicutes, which was diminished by subsequent dietary manipulations that limit weight gain. Microbiota transplantation from mice with DIO to lean germ-free recipients promoted greater fat deposition than transplants from lean donors. Metagenomic and biochemical analysis of the gut microbiome together with sequencing and metabolic reconstructions of a related human gut-associated Mollicute (Eubacterium dolichum) revealed features that may provide a competitive advantage to members of the bloom in the We

SUBMITTER: Turnbaugh PJ 

PROVIDER: S-EPMC3687783 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature