Expression of CD163 prevents apoptosis through the production of granulocyte colony-stimulating factor in meningioma.

ABSTRACT:

Background

CD163 is a 130-kDa transmembrane protein expressed in human monocytes and macrophages, and the aberrant expression of CD163 in breast and colorectal cancer associated with patients' poor prognosis was reported. Here, we analyzed the expression of CD163 in meningioma, a common intracranial tumor, and its molecular mechanism in association with meningioma progression.

Methods

First, we performed immunohistochemical analysis using 50 human meningioma specimens. Next, we established CD163-overexpressing human meningioma cell lines and investigated its roles in tumor progression in vitro and in vivo.

Results

Immunohistochemically, 26 of 50 human meningioma specimens (52.0%) were positive for CD163 in tumor cells, including benign grade I (48.5%) and grade II (71

SUBMITTER: Kanno H 

PROVIDER: S-EPMC3688010 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature