Slit/Robo-mediated chemorepulsion of vagal sensory axons in the fetal gut.

ABSTRACT:

Background

The vagus nerve descends from the brain to the gut during fetal life to reach specific targets in the bowel wall. Vagal sensory axons have been shown to respond to the axon guidance molecule netrin and to its receptor, deleted in colorectal cancer (DCC). As there are regions of the gut wall into which vagal axons do and do not extend, it is likely that a combination of attractive and repellent cues are involved in how vagal axons reach specific targets. We tested the hypothesis that Slit/Robo chemorepulsion can contribute to the restriction of vagal sensory axons to specific targets in the gut wall.

Results

Transcripts encoding Robo1 and Robo2 were expressed in the nodose ganglia throughout development and mRNA encoding the Robo ligands Slit1, Slit2, and Slit3 wer

SUBMITTER: Goldberg D 

PROVIDER: S-EPMC3688041 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature