Adhesins and host serum factors drive Yop translocation by yersinia into professional phagocytes during animal infection.

ABSTRACT: Yersinia delivers Yops into numerous types of cultured cells, but predominantly into professional phagocytes and B cells during animal infection. The basis for this cellular tropism during animal infection is not understood. This work demonstrates that efficient and specific Yop translocation into phagocytes by Yersinia pseudotuberculosis (Yptb) is a multi-factorial process requiring several adhesins and host complement. When WT Yptb or a multiple adhesin mutant strain, ΔailΔinvΔyadA, colonized tissues to comparable levels, ΔailΔinvΔyadA translocated Yops into significantly fewer cells, demonstrating that these adhesins are critical for translocation into high numbers of cells. However, phagocytes were still selectively targeted for translocation, indicating that other bacterial and/or hos

SUBMITTER: Maldonado-Arocho FJ 

PROVIDER: S-EPMC3688556 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature