The MPO-463G>A polymorphism and lung cancer risk: a meta-analysis based on 22 case-control studies.

ABSTRACT:

Background

Myeloperoxidase (MPO) is an endogenous oxidant enzyme that produces reactive oxygen species (ROS) and may be involved in lung carcinogenesis. The MPO-463G>A polymorphism influences MPO transcription and has been associated with lung cancer susceptibility. However, the association between the MPO-463G>A polymorphism and lung cancer risk remains controversial.

Method

To investigate the effect of this polymorphism on lung cancer susceptibility, we performed a meta-analysis based on 22 published case-control studies including 7,520 patients with lung cancer and 8,600 controls. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association.

Results

Overall, there was no evidence for significant association between MPO-4

SUBMITTER: Yang JP 

PROVIDER: S-EPMC3688689 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature