Cellular immunotherapy for refractory hematological malignancies.

ABSTRACT:

Background

Acute myeloid leukemia (AML) and other aggressive refractory hematological malignancies unresponsive to upfront therapy remain difficult conditions to treat. Often, the focus of therapy is centered on achieving complete remission of disease in order to proceed with a consolidative stem cell transplant. At issue with this paradigm is the multitude of patients who are unable to achieve complete remission with standard chemotherapeutic options. A major benefit of transplantation is the graft versus tumor effect that follows successful engraftment. However, with this graft versus tumor effect comes the risk of graft versus host disease. Therefore, alternative treatment options that utilize immunotherapy while minimizing toxicity are warranted. Herein, we propose a novel trea

SUBMITTER: Reagan JL 

PROVIDER: S-EPMC3689050 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature