Oligonol inhibits dextran sulfate sodium-induced colitis and colonic adenoma formation in mice.

ABSTRACT:

Aims

To evaluate the effects of oligonol administration on experimentally induced colitis and colonic adenoma formation.

Results

Oral administration of oligonol protected against mouse colitis induced by dextran sulfate sodium (DSS). Under the same experimental conditions, oligonol administration significantly inhibited the activation of nuclear factor-kappa B and signal transducer and activator of transcription (STAT) 3 and expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and cyclin D1 in the mouse colon. Further, oligonol inhibited azoxymethane-initiated and DSS-promoted adenoma formation in the mouse colon. Oligonol administration also attenuated lipid peroxidation (malondialdehyde) and protein oxidation (4-hydroxy-2-nonenal), thereby preven

SUBMITTER: Yum HW 

PROVIDER: S-EPMC3689162 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature