Enantioselective thiourea-catalyzed intramolecular cope-type hydroamination.

ABSTRACT: Catalysis of Cope-type rearrangements of bis-homoallylic hydroxylamines is demonstrated using chiral thiourea derivatives. This formal intramolecular hydroamination reaction provides access to highly enantioenriched α-substituted pyrrolidine products and represents a complementary approach to metal-catalyzed methods.

SUBMITTER: Brown AR 

PROVIDER: S-EPMC3689223 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature