Common and specific liability to addiction: approaches to association studies of opioid addiction.

ABSTRACT:

Background

Opioid addiction, whether to opiates such as heroin and morphine, and/or to non-medical use of opioids, is a major problem worldwide. Although drug-induced and environmental factors are essential for the liability to develop opioid addiction, the genetic background of an individual is now known also to play a substantial role.

Methods

The overall goal of this article is to address the common and specific liabilities to addiction in the context of approaches to studies of one addiction, opioid addiction. Literature on identifying genetic variants that may play a role in the development of opioid addiction was reviewed.

Results

A substantial number of genetic variants have been reported to be associated with opioid addiction. No single variant has been found

SUBMITTER: Nielsen DA 

PROVIDER: S-EPMC3689423 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature