Development and validation of a semiquantitative brain maturation score on fetal MR images: initial results.

ABSTRACT:

Purpose

To develop a valid, reliable, and simple-to-use semiquantitative visual scale of fetal brain maturation for use in clinical fetal MR imaging assessment and interpretation.

Materials and methods

This is a retrospective assessment of data from a previous study that was prospective, institutional review board approved, and HIPAA compliant. Forty-eight normal pregnancies with a gestational age (GA) of 25 to 35 weeks were studied. A fetal total maturation score (fTMS) was developed by utilizing six subscores that evaluated cortical sulcation, myelination, and the germinal matrix and provided a single combined numerical value to be evaluated as a marker of brain maturity. The fTMS was correlated with GA and segmented brain volume. A regression model that associated GA base

SUBMITTER: Vossough A 

PROVIDER: S-EPMC3689448 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature