Genetic analysis of adiponectin variation and its association with type 2 diabetes in African Americans.

ABSTRACT:

Objective

Adiponectin is an adipocytokine that has been implicated in a variety of metabolic disorders, including T2D and cardiovascular disease. Studies evaluating genetic variants in ADIPOQ have been contradictory when testing association with T2D in different ethnic groups.

Design and methods

In this study, 18 SNPs in ADIPOQ were tested for association with plasma adiponectin levels and diabetes status. SNPs were examined in two independent African-American cohorts (nmax = 1,116) from the Insulin Resistance Atherosclerosis Family Study (IRASFS) and the African American-Diabetes Heart Study (AA-DHS).

Results

Five polymorphisms were nominally associated with plasma adiponectin levels in the meta-analysis (P = 0.035-1.02 × 10(-6) ) including a low frequency arginine t

SUBMITTER: Sandy An S 

PROVIDER: S-EPMC3690163 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature