BCL2 genetic variants are associated with acute kidney injury in septic shock*.

ABSTRACT:

Objective

Acute kidney injury frequently complicates septic shock and independently predicts mortality in this population. Clinical factors alone do not entirely account for differences in risk of acute kidney injury between patients. Genetic variants are likely to explain this differential susceptibility. To identify genetic variants linked to acute kidney injury susceptibility, we conducted a high-density genotyping association study in a large population of patients with septic shock.

Design

Retrospective study.

Setting

Tertiary academic medical center.

Patients

One thousand two hundred and sixty-four patients with septic shock were analyzed to elucidate clinical risk factors associated with the development of acute kidney injury. Among them, 887 Caucasian p

SUBMITTER: Frank AJ 

PROVIDER: S-EPMC3690367 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature