Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer.

ABSTRACT:

Background

We examined host genetic factors to identify those more common in individuals whose human papillomavirus (HPV) infections were most likely to persist and progress to cervical intraepithelial neoplasia grade 3 (CIN3) and cancer.

Methods

We genotyped 92 single-nucleotide polymorphisms (SNPs) from 49 candidate immune response and DNA repair genes obtained from 469 women with CIN3 or cancer, 390 women with persistent HPV infections (median duration, 25 months), and 452 random control subjects from the 10,049-woman Guanacaste Costa Rica Natural History Study. We calculated odds ratios and 95% confidence intervals (CIs) for the association of SNP and haplotypes in women with CIN3 or cancer and HPV persistence, compared with random control subjects.

Results

A SNP

SUBMITTER: Wang SS 

PROVIDER: S-EPMC3690375 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature