Neural correlates of stress-induced and cue-induced drug craving: influences of sex and cocaine dependence.

ABSTRACT:

Objective

Although stress and drug cue exposure each increase drug craving and contribute to relapse in cocaine dependence, no previous research has directly examined the neural correlates of stress-induced and drug cue-induced craving in cocaine-dependent women and men relative to comparison subjects.

Method

Functional MRI was used to assess responses to individualized scripts for stress, drug/alcohol cue and neutral-relaxing-imagery conditions in 30 abstinent cocaine-dependent individuals (16 women, 14 men) and 36 healthy recreational-drinking comparison subjects (18 women, 18 men).

Results

Significant three-way interactions between diagnostic group, sex, and script condition were observed in multiple brain regions including the striatum, insula, and anterior and po

SUBMITTER: Potenza MN 

PROVIDER: S-EPMC3690485 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature