The neuroimaging signal is a linear sum of neurally distinct stimulus- and task-related components.

ABSTRACT: Neuroimaging (for example, functional magnetic resonance imaging) signals are taken as a uniform proxy for local neural activity. By simultaneously recording electrode and neuroimaging (intrinsic optical imaging) signals in alert, task-engaged macaque visual cortex, we recently observed a large anticipatory trial-related neuroimaging signal that was poorly related to local spiking or field potentials. We used these same techniques to study the interactions of this trial-related signal with stimulus-evoked responses over the full range of stimulus intensities, including total darkness. We found that the two signals could be separated, and added linearly over this full range. The stimulus-evoked component was related linearly to local spiking and, consequently, could be used to obtain precis

SUBMITTER: Cardoso MM 

PROVIDER: S-EPMC3690535 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature