High-resolution quantitative metabolome analysis of urine by automated flow injection NMR.

ABSTRACT: Metabolism is essential to understand human health. To characterize human metabolism, a high-resolution read-out of the metabolic status under various physiological conditions, either in health or disease, is needed. Metabolomics offers an unprecedented approach for generating system-specific biochemical definitions of a human phenotype through the capture of a variety of metabolites in a single measurement. The emergence of large cohorts in clinical studies increases the demand of technologies able to analyze a large number of measurements, in an automated fashion, in the most robust way. NMR is an established metabolomics tool for obtaining metabolic phenotypes. Here, we describe the analysis of NMR-based urinary profiles for metabolic studies, challenged to a large human study (3007 sam

SUBMITTER: Da Silva L 

PROVIDER: S-EPMC3690541 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature