Increased expression of epidermal growth factor receptor (EGF-R) in patients with different forms of lung fibrosis.

ABSTRACT:

Introduction

Emerging evidence supports the role of epidermal growth factor-receptor (EGFR) in fibrogenesis. The aim of our study was to investigate the expression profiles of EGFR in three forms of IIPs, including idiopathic pulmonary fibrosis (IPF), cryptogenic organizing pneumonia (COP), and nonspecific interstitial pneumonia (NSIP).

Patients and methods

Twenty newly diagnosed patients with IPF, 15 with COP, and 15 with NSIP (cellular, n = 4 and fibrotic, n = 11) were investigated. Fifteen paraffin blocks obtained from the normal part of lungs removed for benign lesions were used as controls. Immunohistochemistry was carried out using specific monoclonal antibody. Results were verified by qRT-PCR.

Results

A significant EGFR upregulation, both in protein and mRNA le

SUBMITTER: Tzouvelekis A 

PROVIDER: S-EPMC3690645 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature