Gastric precancerous lesions are associated with gene variants in Helicobacter pylori-susceptible ethnic Malays.

ABSTRACT:

Aim

To identify genes associated with gastric precancerous lesions in Helicobacter pylori (H. pylori)-susceptible ethnic Malays.

Methods

Twenty-three Malay subjects with H. pylori infection and gastric precancerous lesions identified during endoscopy were included as "cases". Thirty-seven Malay subjects who were H. pylori negative and had no precancerous lesions were included as "controls". Venous blood was collected for genotyping with Affymetrix 50K Xba1 kit. Genotypes with call rates < 90% for autosomal single nucleotide polymorphisms (SNPs) were excluded. For each precancerous lesion, associated SNPs were identified from Manhattan plots, and only SNPs with a χ² P value < 0.05 and Hardy Weinberg Equilibrium P value > 0.5 was considered as significant markers.

Results</

SUBMITTER: Maran S 

PROVIDER: S-EPMC3691040 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature