Genetic analysis of vertebral trabecular bone density and cross-sectional area in older men.

ABSTRACT: We investigated 383 bone candidate genes for associations between single nucleotide polymorphisms and vertebral trabecular volumetric bone mineral density (vBMD) and cross-sectional area (CSA) in 2,018 Caucasian men aged ≥ 65 years. SNPs in TGFBR3, SOST, KL, CALCR, LEP, CSF1R, PTN, GNRH2, FGFR2, and MEPE were associated with vBMD and SNPs in CYP11B1, DVL2, DLX5, WNT4, and PAX7 were associated with CSA in independent study samples (p < 0.005).

Inroduction

Vertebral bone mineral density and cross-sectional area are important determinants of vertebral bone strength. Little is known about the specific genetic variants that influence these phenotypes in humans.

Methods

We investigated the potential genetic variants associated with vertebral trabecular volumetric BMD and CSA measur

SUBMITTER: Zmuda JM 

PROVIDER: S-EPMC3691107 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature