Gogo receptor contributes to retinotopic map formation and prevents R1-6 photoreceptor axon bundling.

ABSTRACT:

Background

Topographic maps form the basis of neural processing in sensory systems of both vertebrate and invertebrate species. In the Drosophila visual system, neighboring R1-R6 photoreceptor axons innervate adjacent positions in the first optic ganglion, the lamina, and thereby represent visual space as a continuous map in the brain. The mechanisms responsible for the establishment of retinotopic maps remain incompletely understood.

Results

Here, we show that the receptor Golden goal (Gogo) is required for R axon lamina targeting and cartridge elongation in a partially redundant fashion with local guidance cues provided by neighboring axons. Loss of function of Gogo in large clones of R axons results in aberrant R1-R6 fascicle spacing. Gogo affects target cartridge selecti

SUBMITTER: Hein I 

PROVIDER: S-EPMC3691217 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature