Association of maternal vitamin D status during pregnancy with bone-mineral content in offspring: a prospective cohort study.

ABSTRACT:

Background

Maternal vitamin D status in pregnancy is a suggested determinant of bone-mineral content (BMC) in offspring, but has been assessed in small studies. We investigated this association in a large prospective study.

Methods

Eligible participants were mother-and-singleton-offspring pairs who had participated in the Avon Longitudinal Study of Parents and Children, and in which the mother had recorded measurements of 25(OH)D concentration in pregnancy and the offspring had undergone dual-energy x-ray absorptiometry at age 9-10 years. 25(OH)D concentrations in pregnancy were assessed per 10·0 nmol/L and classified as sufficient (more than 50·00 nmol/L), insufficient (49·99-27·50 nmol/L), or deficient (lower than 27·50 nmol/L). Associations between maternal serum 25(OH)D

SUBMITTER: Lawlor DA 

PROVIDER: S-EPMC3691477 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature