MicroRNA expression profiles identify subtypes of mantle cell lymphoma with different clinicobiological characteristics.

ABSTRACT:

Purpose

microRNAs (miRNA) are posttranscriptional gene regulators that may be useful as diagnostic and/or prognostic biomarkers. We aim to study the expression profiles of a high number of miRNAs and their relationship with clinicopathologic and biologic relevant features in leukemic mantle cell lymphomas (MCL).

Experimental design

Expression profiling of 664 miRNAs was investigated using a high-throughput quantitative real-time PCR platform in 30 leukemic MCLs. Statistical and bioinformatic analyses were conducted to define miRNAs associated with different clinicopathologic parameters. Gene expression profiling was investigated by microarrays in 16 matching cases to study the potential genes and pathways targeted by selected miRNAs. The prognostic value of miR-34a was inves

SUBMITTER: Navarro A 

PROVIDER: S-EPMC3691513 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature