Gene expression profiles in canine mammary carcinomas of various grades of malignancy.

ABSTRACT:

Background

The frequency of mammary malignancies in canine patients is even three times over than in human. In various types of cancer different intracellular signalling pathways are perturbed, thus the patients with pathologically the same type of cancer often have dissimilar genetic defects in their tumours and respond in a heterogeneous manner to anticancer treatment. That is why the objective of the hereby study was to assess the gene expression profiles in canine mammary carcinomas (in unsupervised manner) classified by pathologists as grade 1 (well differentiated), grade 2 (moderately differentiated) and grade 3 (poorly differentiated) and compare their molecular and pathological classifications.

Results

Our unsupervised analysis classified the examined tissues into th

SUBMITTER: Pawlowski KM 

PROVIDER: S-EPMC3691656 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature