Protein expression profiling of nuclear membrane protein reveals potential biomarker of human hepatocellular carcinoma.

ABSTRACT:

Background

Complex molecular events lead to development and progression of liver cirrhosis to HCC. Differentially expressed nuclear membrane associated proteins are responsible for the functional and structural alteration during the progression from cirrhosis to carcinoma. Although alterations/ post translational modifications in protein expression have been extensively quantified, complementary analysis of nuclear membrane proteome changes have been limited. Deciphering the molecular mechanism that differentiate between normal and disease state may lead to identification of biomarkers for carcinoma.

Results

Many proteins displayed differential expression when nuclear membrane proteome of hepatocellular carcinoma (HCC), fibrotic liver, and HepG2 cell line were assessed using

SUBMITTER: Khan R 

PROVIDER: S-EPMC3691657 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature