Pathways to neurodegeneration: effects of HIV and aging on resting-state functional connectivity.

ABSTRACT:

Objective

Resting-state functional connectivity MRI (rs-fcMRI) may provide insight into the neurophysiology of HIV and aging.

Methods

In this cross-sectional study, we used rs-fcMRI to investigate intra- and internetwork connectivity among 5 functional brain networks in 58 HIV-infected (HIV+) participants (44% receiving highly active antiretroviral therapy) and 53 HIV-uninfected (HIV-) controls. An analysis of covariance assessed the relationship among age, HIV laboratory markers, or degree of cognitive impairment and brain networks.

Results

Individuals who were HIV+ had decreased rs-fcMRI intranetwork correlations in the default mode (DMN, p = 0.01), control (CON, p = 0.02), and salience (SAL, p = 0.02) networks, but showed no changes in the sensorimotor (SMN) or dor

SUBMITTER: Thomas JB 

PROVIDER: S-EPMC3691785 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature