An orphan viral TNF receptor superfamily member identified in lymphocystis disease virus.

ABSTRACT:

Background

Lymphocystis disease virus (LCDV) is a large icosahedral dsDNA-containing virus of the Lymphocystivirus genus within the Iridoviridae family that can cause disease in more than 140 marine and freshwater fish species. While several isolates have been charcaterized and classified into distinct genotypes the complete genomic sequence is currently only available from two species, the LCDV-1, isolated from flounder (Platichtys flesus) in Europe and the LCDV-C, isolated from Japanese cultured flounder (Paralichthys olivaceus) in China. Analysis of the genome of LCDV-C showed it to encode a protein named LDVICp016 with similarities to the Tumour necrosis factor receptor (TNFR) superfamily with immunomodulatory potential.

Findings

We have expressed and purified the recomb

SUBMITTER: Pontejo SM 

PROVIDER: S-EPMC3691878 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature