Nigral stimulation for resistant axial motor impairment in Parkinson's disease? A randomized controlled trial.

ABSTRACT: Gait and balance disturbances typically emerge in advanced Parkinson's disease with generally limited response to dopaminergic medication and subthalamic nucleus deep brain stimulation. Therefore, advanced programming with interleaved pulses was put forward to introduce concomittant nigral stimulation on caudal contacts of a subthalamic lead. Here, we hypothesized that the combined stimulation of subthalamic nucleus and substantia nigra pars reticulata improves axial symptoms compared with standard subthalamic nucleus stimulation. Twelve patients were enrolled in this 2 × 2 cross-over double-blind randomized controlled clinical trial and both the safety and efficacy of combined subthalamic nucleus and substantia nigra pars reticulata stimulation were evaluated compared with standard subtha

SUBMITTER: Weiss D 

PROVIDER: S-EPMC3692032 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature