WebPDBinder: a server for the identification of ligand binding sites on protein structures.

ABSTRACT: The webPDBinder (http://pdbinder.bio.uniroma2.it/PDBinder) is a web server for the identification of small ligand-binding sites in a protein structure. webPDBinder searches a protein structure against a library of known binding sites and a collection of control non-binding pockets. The number of similarities identified with the residues in the two sets is then used to derive a propensity value for each residue of the query protein associated to the likelihood that the residue is part of a ligand binding site. The predicted binding residues can be further refined using conservation scores derived from the multiple alignment of the PFAM protein family. webPDBinder correctly identifies residues belonging to the binding site in 77% of the cases and is able to identify binding pockets starting

SUBMITTER: Bianchi V 

PROVIDER: S-EPMC3692056 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature