BeAtMuSiC: Prediction of changes in protein-protein binding affinity on mutations.

ABSTRACT: The ability of proteins to establish highly selective interactions with a variety of (macro)molecular partners is a crucial prerequisite to the realization of their biological functions. The availability of computational tools to evaluate the impact of mutations on protein-protein binding can therefore be valuable in a wide range of industrial and biomedical applications, and help rationalize the consequences of non-synonymous single-nucleotide polymorphisms. BeAtMuSiC (http://babylone.ulb.ac.be/beatmusic) is a coarse-grained predictor of the changes in binding free energy induced by point mutations. It relies on a set of statistical potentials derived from known protein structures, and combines the effect of the mutation on the strength of the interactions at the interface, and on the ove

SUBMITTER: Dehouck Y 

PROVIDER: S-EPMC3692068 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature