MISTIC: Mutual information server to infer coevolution.

ABSTRACT: MISTIC (mutual information server to infer coevolution) is a web server for graphical representation of the information contained within a MSA (multiple sequence alignment) and a complete analysis tool for Mutual Information networks in protein families. The server outputs a graphical visualization of several information-related quantities using a circos representation. This provides an integrated view of the MSA in terms of (i) the mutual information (MI) between residue pairs, (ii) sequence conservation and (iii) the residue cumulative and proximity MI scores. Further, an interactive interface to explore and characterize the MI network is provided. Several tools are offered for selecting subsets of nodes from the network for visualization. Node coloring can be set to match different attr

SUBMITTER: Simonetti FL 

PROVIDER: S-EPMC3692073 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature