IL6 and IL10 are genetic susceptibility factors of periodontal disease.

ABSTRACT:

Background

Periodontitis is a disease mainly caused by a chronic infection of tissues that support the teeth. Several factors, such as diabetes, smoking and oral care, as well as genetic susceptibility can influence both the risk to develop periodontitis and its progression. The aim of the investigation was to test whether alleles of candidate genes were associated with periodontitis.

Materials and methods

A case control study was performed with a cohort of 184 patients with chronic periodontitis and 231 healthy controls from the Italian population. A total of six single nucleotide polymorphisms from five candidate genes, i.e., IL1A, IL1B, IL6, IL10 and vitamin D receptor, were investigated.

Results

Evidence of association were obtained for rs1800795 mapping in IL6 (P

SUBMITTER: Scapoli L 

PROVIDER: S-EPMC3692173 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature