Mapping molecular association networks of nervous system diseases via large-scale analysis of published research.

ABSTRACT: Network medicine has been applied successfully to elicit the structure of large-scale molecular interaction networks. Its main proponents have claimed that this approach to integrative medical investigation should make it possible to identify functional modules of interacting molecular biological units as well as interactions themselves. This paper takes a significant step in this direction. Based on a large-scale analysis of the nervous system molecular medicine literature, this study analyzes and visualizes the complex structure of associations between diseases on the one hand and all types of molecular substances on the other. From this analysis it then identifies functional co-association groups consisting of several types of molecular substances, each consisting of substances that exh

SUBMITTER: Hu X 

PROVIDER: S-EPMC3692415 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature