Tissue-specific 5' heterogeneity of PPARα transcripts and their differential regulation by leptin.

ABSTRACT: The genes encoding nuclear receptors comprise multiple 5'untranslated exons, which give rise to several transcripts encoding the same protein, allowing tissue-specific regulation of expression. Both human and mouse peroxisome proliferator activated receptor (PPAR) α genes have multiple promoters, although their function is unknown. Here we have characterised the rat PPARα promoter region and have identified three alternative PPARα transcripts, which have different transcription start sites owing to the utilisation of distinct first exons. Moreover these alternative PPARα transcripts were differentially expressed between adipose tissue and liver. We show that while the major adipose (P1) and liver (P2) transcripts were both induced by dexamethasone, they were differentially regulated by the

SUBMITTER: Garratt ES 

PROVIDER: S-EPMC3692471 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature