Meta-analyses of the 5-HTTLPR polymorphisms and post-traumatic stress disorder.

ABSTRACT:

Objective

To conduct a meta-analysis of all published genetic association studies of 5-HTTLPR polymorphisms performed in PTSD cases.

Methods data sources

Potential studies were identified through PubMed/MEDLINE, EMBASE, Web of Science databases (Web of Knowledge, WoK), PsychINFO, PsychArticles and HuGeNet (Human Genome Epidemiology Network) up until December 2011.

Study selection

Published observational studies reporting genotype or allele frequencies of this genetic factor in PTSD cases and in non-PTSD controls were all considered eligible for inclusion in this systematic review.

Data extraction

Two reviewers selected studies for possible inclusion and extracted data independently following a standardized protocol.

Statistical analysis

A biallelic and a

SUBMITTER: Navarro-Mateu F 

PROVIDER: S-EPMC3692498 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature