Insulin hypersensitivity induced by hepatic PTEN gene ablation protects from murine endotoxemia.

ABSTRACT: Sepsis still remains a major cause for morbidity and mortality in patients. The molecular mechanisms underlying the disease are still enigmatic. A great number of therapeutic approaches have failed and treatment strategies are limited to date. Among those few admitted for clinical intervention, intensive insulin treatment has proven to be effective in the reduction of disease related complications in critically ill patients. Insulin effectively reduces glucose levels and thereby contributes to protection. On the other hand insulin is a potent signaling pathway activator. One of those is the PI3K signaling axis. Activation of PI3K is known to limit pro-inflammatory gene expression. Here we can show that in a mouse model of insulin hypersensitivity induced by the deletion of the PI3K antagon

SUBMITTER: Guenzl PM 

PROVIDER: S-EPMC3692528 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature