MicroRNA-gene expression network in murine liver during Schistosoma japonicum infection.

ABSTRACT:

Background

Schistosomiasis japonica remains a significant public health problem in China and Southeast Asian countries. The most typical and serious outcome of the chronic oriental schistosomiasis is the progressive granuloma and fibrosis in the host liver, which has been a major medical challenge. However, the molecular mechanism underling the hepatic pathogenesis is still not clear.

Methodology and principal findings

Using microarrays, we quantified the temporal gene expression profiles in the liver of Schistosoma japonicum-infected BALB/c mice at 15, 30, and 45 day post infection (dpi) with that from uninfected mice as controls. Gene expression alternation associated with liver damage was observed in the initial phase of infection (dpi 15), which became more magnificent w

SUBMITTER: Cai P 

PROVIDER: S-EPMC3692539 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature