A common missense variant in the neuregulin 1 gene is associated with both schizophrenia and sudden cardiac death.

ABSTRACT:

Background

Both schizophrenia and epilepsy have been linked to increased risk of sudden cardiac death (SCD). We hypothesized that DNA variants within genes previously associated with schizophrenia and epilepsy may contribute to an increased risk of SCD.

Objective

To investigate the contribution to SCD susceptibility of DNA variants previously implicated in schizophrenia and epilepsy.

Methods

From the ongoing Oregon Sudden Unexpected Death Study, comparisons were performed among 340 SCD cases presenting with ventricular fibrillation and 342 controls. We tested for the association between 17 single-nucleotide polymorphisms (SNPs) mapped to 14 loci previously implicated in schizophrenia and epilepsy by using logistic regression and assuming additive, dominant, and recess

SUBMITTER: Huertas-Vazquez A 

PROVIDER: S-EPMC3692570 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature