Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens.

ABSTRACT:

Rationale

The nucleus accumbens (NAc) is a site critical for the actions of many drugs of abuse. Psychoactive compounds, such as N-methyl-D-aspartate receptor (NMDAR) antagonists, modify gamma (40-90) and high frequency oscillations (HFO, 130-180 Hz) in local field potentials (LFPs) recorded in the NAc. Lysergic acid diethylamide (LSD) and 2,5-dimethoxy-4-iodoamphetamine (DOI) are serotonergic hallucinogens and activation of 5HT2A receptors likely underlies their hallucinogenic effects. Whether these compounds can also modulate LFP oscillations in the NAc is unclear.

Objective

This study aims to examine the effect of serotonergic hallucinogens on gamma and HFO recorded in the NAc and to test whether 5HT2A receptors mediate the effects observed.

Methods

LFPs were recor

SUBMITTER: Goda SA 

PROVIDER: S-EPMC3693439 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature