Effect of statin therapy in reducing the risk of serious non-AIDS-defining events and nonaccidental death.

ABSTRACT:

Background

Excessive inflammation persists despite antiretroviral treatment. Statins decrease cardiovascular (CV) disease risk by reducing low-density lipoprotein cholesterol and inflammation. We performed an exploratory analysis to evaluate whether statin therapy decreased risk of non-AIDS-defining events and nonaccidental death.

Methods

A total of 3601 subjects not on a statin from the AIDS Clinical Trials Group Longitudinal Linked Randomized Trials cohort were included. Outcome was time to first clinical event (CV event, renal or hepatic disease, incident diabetes, thrombotic/embolic event, nontraumatic fracture, non-AIDS-defining malignancy, serious bacterial infection, or nonaccidental death); event categories were also analyzed separately. Inverse probability of treatm

SUBMITTER: Overton ET 

PROVIDER: S-EPMC3693493 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature