Ontology highlight
ABSTRACT:
SUBMITTER: Dibble CC
PROVIDER: S-EPMC3693578 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Molecular cell 20120712 4
The tuberous sclerosis complex (TSC) tumor suppressors form the TSC1-TSC2 complex, which limits cell growth in response to poor growth conditions. Through its GTPase-activating protein (GAP) activity toward Rheb, this complex inhibits the mechanistic target of rapamycin (mTOR) complex 1 (mTORC1), a key promoter of cell growth. Here, we identify and biochemically characterize TBC1D7 as a stably associated and ubiquitous third core subunit of the TSC1-TSC2 complex. We demonstrate that the TSC1-TSC ...[more]