Attenuation of live respiratory syncytial virus vaccines is associated with reductions in levels of nasal cytokines.

ABSTRACT:

Background

Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract illness (LRTI) in children. Several promising live-attenuated RSV vaccines are in development. Defining additional markers of attenuation could enhance clinical trials.

Methods

We used clinical data, virologic data, and nasal wash (NW) specimens from 20 RSV-naive children enrolled in studies of 4 live-attenuated RSV vaccines. Seven received minimally attenuated cpts248/955 or cpts530/1009 (group 1), 6 received moderately attenuated cpts248/404 (group 2), and 7 received highly attenuated rA2cp248/404/1030/ΔSH (group 3). NW specimens were tested for cytokines and chemokines via an electrochemiluminescence biosensor assay.

Results

Group 1 exhibited 1 instance of LRTI and significan

SUBMITTER: Karron RA 

PROVIDER: S-EPMC3693589 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature