Resistance training and pioglitazone lead to improvements in muscle power during voluntary weight loss in older adults.

ABSTRACT:

Background

The prevalence of obesity in older adults is increasing but concerns exist about the effect of weight loss on muscle function. Demonstrating that muscle strength and power are not adversely affected during "intentional" weight loss in older adults is important given the wide-ranging negative health effects of excess adiposity.

Methods

Participants (N = 88; age = 70.6 ± 3.6 years; body mass index = 32.8 ± 4.5 kg/m(2)) were randomly assigned to one of four intervention groups: pioglitazone or placebo and resistance training (RT) or no RT, while undergoing intentional weight loss via a hypocaloric diet. Outcomes were leg press power and isometric knee extensor strength. Analysis of covariance, controlling for baseline values, compared follow-up means of power and str

SUBMITTER: Marsh AP 

PROVIDER: S-EPMC3693600 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature